Interactive binding mode exploration
Description
Below is the representation of the non-bounded interactions between ligands and residues in the ATP binding site of the selected protein kinase. Each of the 85 residues is represented by eight types of interactions:
- (Column 0) hydrophobic contacts (HYD)
- (Column 1) aromatic face to face (AFF)
- (Column 2) aromatic edge to face (AEF)
- (Column 3) hydrogen bond with protein as hydrogen bond donor (HBD)
- (Column 4) hydrogen bond with protein as hydrogen bond acceptor (HBA)
- (Column 5) salt bridges with positively charged protein (PSB)
- (Column 6) salt bridges with negatively charged protein (NSB)
- (Column 7) salt bridges having an ionic bond with metal ion (ISB)
Interactions are encoded in two colors:
Absence of interaction
Presence of interaction
To get all residues, the user can zoom on the heatmap by selecting an area.
To visualize all information, including bioactivity data on a ligand-target pair, the user can click anywhere on a row of the heatmap.
(see User Guide for complete information about non-bounded interaction in KinoMine).
Export data from heatmap :
32_HYD 32_AFF 32_AEF 32_HBD 32_HBA 32_PSB 32_NSB 32_ISB 33_HYD 33_AFF 33_AEF 33_HBD 33_HBA 33_PSB 33_NSB 33_ISB 34_HYD 34_AFF 34_AEF 34_HBD 34_HBA 34_PSB 34_NSB 34_ISB 47_HYD 47_AFF 47_AEF 47_HBD 47_HBA 47_PSB 47_NSB 47_ISB 48_HYD 48_AFF 48_AEF 48_HBD 48_HBA 48_PSB 48_NSB 48_ISB 49_HYD 49_AFF 49_AEF 49_HBD 49_HBA 49_PSB 49_NSB 49_ISB 50_HYD 50_AFF 50_AEF 50_HBD 50_HBA 50_PSB 50_NSB 50_ISB 53_HYD 53_AFF 53_AEF 53_HBD 53_HBA 53_PSB 53_NSB 53_ISB 54_HYD 54_AFF 54_AEF 54_HBD 54_HBA 54_PSB 54_NSB 54_ISB 55_HYD 55_AFF 55_AEF 55_HBD 55_HBA 55_PSB 55_NSB 55_ISB 56_HYD 56_AFF 56_AEF 56_HBD 56_HBA 56_PSB 56_NSB 56_ISB 57_HYD 57_AFF 57_AEF 57_HBD 57_HBA 57_PSB 57_NSB 57_ISB 58_HYD 58_AFF 58_AEF 58_HBD 58_HBA 58_PSB 58_NSB 58_ISB 92_HYD 92_AFF 92_AEF 92_HBD 92_HBA 92_PSB 92_NSB 92_ISB 93_HYD 93_AFF 93_AEF 93_HBD 93_HBA 93_PSB 93_NSB 93_ISB 94_HYD 94_AFF 94_AEF 94_HBD 94_HBA 94_PSB 94_NSB 94_ISB 95_HYD 95_AFF 95_AEF 95_HBD 95_HBA 95_PSB 95_NSB 95_ISB 96_HYD 96_AFF 96_AEF 96_HBD 96_HBA 96_PSB 96_NSB 96_ISB 97_HYD 97_AFF 97_AEF 97_HBD 97_HBA 97_PSB 97_NSB 97_ISB 133_HYD 133_AFF 133_AEF 133_HBD 133_HBA 133_PSB 133_NSB 133_ISB 134_HYD 134_AFF 134_AEF 134_HBD 134_HBA 134_PSB 134_NSB 134_ISB 135_HYD 135_AFF 135_AEF 135_HBD 135_HBA 135_PSB 135_NSB 135_ISB 136_HYD 136_AFF 136_AEF 136_HBD 136_HBA 136_PSB 136_NSB 136_ISB 137_HYD 137_AFF 137_AEF 137_HBD 137_HBA 137_PSB 137_NSB 137_ISB 138_HYD 138_AFF 138_AEF 138_HBD 138_HBA 138_PSB 138_NSB 138_ISB 139_HYD 139_AFF 139_AEF 139_HBD 139_HBA 139_PSB 139_NSB 139_ISB 140_HYD 140_AFF 140_AEF 140_HBD 140_HBA 140_PSB 140_NSB 140_ISB 141_HYD 141_AFF 141_AEF 141_HBD 141_HBA 141_PSB 141_NSB 141_ISB 142_HYD 142_AFF 142_AEF 142_HBD 142_HBA 142_PSB 142_NSB 142_ISB 145_HYD 145_AFF 145_AEF 145_HBD 145_HBA 145_PSB 145_NSB 145_ISB 146_HYD 146_AFF 146_AEF 146_HBD 146_HBA 146_PSB 146_NSB 146_ISB 147_HYD 147_AFF 147_AEF 147_HBD 147_HBA 147_PSB 147_NSB 147_ISB 164_HYD 164_AFF 164_AEF 164_HBD 164_HBA 164_PSB 164_NSB 164_ISB 165_HYD 165_AFF 165_AEF 165_HBD 165_HBA 165_PSB 165_NSB 165_ISB 166_HYD 166_AFF 166_AEF 166_HBD 166_HBA 166_PSB 166_NSB 166_ISB 167_HYD 167_AFF 167_AEF 167_HBD 167_HBA 167_PSB 167_NSB 167_ISB 168_HYD 168_AFF 168_AEF 168_HBD 168_HBA 168_PSB 168_NSB 168_ISB 169_HYD 169_AFF 169_AEF 169_HBD 169_HBA 169_PSB 169_NSB 169_ISB 170_HYD 170_AFF 170_AEF 170_HBD 170_HBA 170_PSB 170_NSB 170_ISB 171_HYD 171_AFF 171_AEF 171_HBD 171_HBA 171_PSB 171_NSB 171_ISB 172_HYD 172_AFF 172_AEF 172_HBD 172_HBA 172_PSB 172_NSB 172_ISB 400_HYD 400_AFF 400_AEF 400_HBD 400_HBA 400_PSB 400_NSB 400_ISB 401_HYD 401_AFF 401_AEF 401_HBD 401_HBA 401_PSB 401_NSB 401_ISB 402_HYD 402_AFF 402_AEF 402_HBD 402_HBA 402_PSB 402_NSB 402_ISB 403_HYD 403_AFF 403_AEF 403_HBD 403_HBA 403_PSB 403_NSB 403_ISB 404_HYD 404_AFF 404_AEF 404_HBD 404_HBA 404_PSB 404_NSB 404_ISB 405_HYD 405_AFF 405_AEF 405_HBD 405_HBA 405_PSB 405_NSB 405_ISB 406_HYD 406_AFF 406_AEF 406_HBD 406_HBA 406_PSB 406_NSB 406_ISB 407_HYD 407_AFF 407_AEF 407_HBD 407_HBA 407_PSB 407_NSB 407_ISB 409_HYD 409_AFF 409_AEF 409_HBD 409_HBA 409_PSB 409_NSB 409_ISB 410_HYD 410_AFF 410_AEF 410_HBD 410_HBA 410_PSB 410_NSB 410_ISB 411_HYD 411_AFF 411_AEF 411_HBD 411_HBA 411_PSB 411_NSB 411_ISB 412_HYD 412_AFF 412_AEF 412_HBD 412_HBA 412_PSB 412_NSB 412_ISB 413_HYD 413_AFF 413_AEF 413_HBD 413_HBA 413_PSB 413_NSB 413_ISB 414_HYD 414_AFF 414_AEF 414_HBD 414_HBA 414_PSB 414_NSB 414_ISB 415_HYD 415_AFF 415_AEF 415_HBD 415_HBA 415_PSB 415_NSB 415_ISB 416_HYD 416_AFF 416_AEF 416_HBD 416_HBA 416_PSB 416_NSB 416_ISB 417_HYD 417_AFF 417_AEF 417_HBD 417_HBA 417_PSB 417_NSB 417_ISB 418_HYD 418_AFF 418_AEF 418_HBD 418_HBA 418_PSB 418_NSB 418_ISB 562_HYD 562_AFF 562_AEF 562_HBD 562_HBA 562_PSB 562_NSB 562_ISB 563_HYD 563_AFF 563_AEF 563_HBD 563_HBA 563_PSB 563_NSB 563_ISB 564_HYD 564_AFF 564_AEF 564_HBD 564_HBA 564_PSB 564_NSB 564_ISB 565_HYD 565_AFF 565_AEF 565_HBD 565_HBA 565_PSB 565_NSB 565_ISB 566_HYD 566_AFF 566_AEF 566_HBD 566_HBA 566_PSB 566_NSB 566_ISB 578_HYD 578_AFF 578_AEF 578_HBD 578_HBA 578_PSB 578_NSB 578_ISB 579_HYD 579_AFF 579_AEF 579_HBD 579_HBA 579_PSB 579_NSB 579_ISB 580_HYD 580_AFF 580_AEF 580_HBD 580_HBA 580_PSB 580_NSB 580_ISB 581_HYD 581_AFF 581_AEF 581_HBD 581_HBA 581_PSB 581_NSB 581_ISB 582_HYD 582_AFF 582_AEF 582_HBD 582_HBA 582_PSB 582_NSB 582_ISB 583_HYD 583_AFF 583_AEF 583_HBD 583_HBA 583_PSB 583_NSB 583_ISB 584_HYD 584_AFF 584_AEF 584_HBD 584_HBA 584_PSB 584_NSB 584_ISB 585_HYD 585_AFF 585_AEF 585_HBD 585_HBA 585_PSB 585_NSB 585_ISB 586_HYD 586_AFF 586_AEF 586_HBD 586_HBA 586_PSB 586_NSB 586_ISB 587_HYD 587_AFF 587_AEF 587_HBD 587_HBA 587_PSB 587_NSB 587_ISB 588_HYD 588_AFF 588_AEF 588_HBD 588_HBA 588_PSB 588_NSB 588_ISB 589_HYD 589_AFF 589_AEF 589_HBD 589_HBA 589_PSB 589_NSB 589_ISB 590_HYD 590_AFF 590_AEF 590_HBD 590_HBA 590_PSB 590_NSB 590_ISB 591_HYD 591_AFF 591_AEF 591_HBD 591_HBA 591_PSB 591_NSB 591_ISB 622_HYD 622_AFF 622_AEF 622_HBD 622_HBA 622_PSB 622_NSB 622_ISB 623_HYD 623_AFF 623_AEF 623_HBD 623_HBA 623_PSB 623_NSB 623_ISB 624_HYD 624_AFF 624_AEF 624_HBD 624_HBA 624_PSB 624_NSB 624_ISB 625_HYD 625_AFF 625_AEF 625_HBD 625_HBA 625_PSB 625_NSB 625_ISB 626_HYD 626_AFF 626_AEF 626_HBD 626_HBA 626_PSB 626_NSB 626_ISB 627_HYD 627_AFF 627_AEF 627_HBD 627_HBA 627_PSB 627_NSB 627_ISB 628_HYD 628_AFF 628_AEF 628_HBD 628_HBA 628_PSB 628_NSB 628_ISB 6ZGC_D_H8H_1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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| 32_HYD | 32_AFF | 32_AEF | 32_HBD | 32_HBA | 32_PSB | 32_NSB | 32_ISB | 33_HYD | 33_AFF | 33_AEF | 33_HBD | 33_HBA | 33_PSB | 33_NSB | 33_ISB | 34_HYD | 34_AFF | 34_AEF | 34_HBD | 34_HBA | 34_PSB | 34_NSB | 34_ISB | 47_HYD | 47_AFF | 47_AEF | 47_HBD | 47_HBA | 47_PSB | 47_NSB | 47_ISB | 48_HYD | 48_AFF | 48_AEF | 48_HBD | 48_HBA | 48_PSB | 48_NSB | 48_ISB | 49_HYD | 49_AFF | 49_AEF | 49_HBD | 49_HBA | 49_PSB | 49_NSB | 49_ISB | 50_HYD | 50_AFF | 50_AEF | 50_HBD | 50_HBA | 50_PSB | 50_NSB | 50_ISB | 53_HYD | 53_AFF | 53_AEF | 53_HBD | 53_HBA | 53_PSB | 53_NSB | 53_ISB | 54_HYD | 54_AFF | 54_AEF | 54_HBD | 54_HBA | 54_PSB | 54_NSB | 54_ISB | 55_HYD | 55_AFF | 55_AEF | 55_HBD | 55_HBA | 55_PSB | 55_NSB | 55_ISB | 56_HYD | 56_AFF | 56_AEF | 56_HBD | 56_HBA | 56_PSB | 56_NSB | 56_ISB | 57_HYD | 57_AFF | 57_AEF | 57_HBD | 57_HBA | 57_PSB | 57_NSB | 57_ISB | 58_HYD | 58_AFF | 58_AEF | 58_HBD | 58_HBA | 58_PSB | 58_NSB | 58_ISB | 92_HYD | 92_AFF | 92_AEF | 92_HBD | 92_HBA | 92_PSB | 92_NSB | 92_ISB | 93_HYD | 93_AFF | 93_AEF | 93_HBD | 93_HBA | 93_PSB | 93_NSB | 93_ISB | 94_HYD | 94_AFF | 94_AEF | 94_HBD | 94_HBA | 94_PSB | 94_NSB | 94_ISB | 95_HYD | 95_AFF | 95_AEF | 95_HBD | 95_HBA | 95_PSB | 95_NSB | 95_ISB | 96_HYD | 96_AFF | 96_AEF | 96_HBD | 96_HBA | 96_PSB | 96_NSB | 96_ISB | 97_HYD | 97_AFF | 97_AEF | 97_HBD | 97_HBA | 97_PSB | 97_NSB | 97_ISB | 133_HYD | 133_AFF | 133_AEF | 133_HBD | 133_HBA | 133_PSB | 133_NSB | 133_ISB | 134_HYD | 134_AFF | 134_AEF | 134_HBD | 134_HBA | 134_PSB | 134_NSB | 134_ISB | 135_HYD | 135_AFF | 135_AEF | 135_HBD | 135_HBA | 135_PSB | 135_NSB | 135_ISB | 136_HYD | 136_AFF | 136_AEF | 136_HBD | 136_HBA | 136_PSB | 136_NSB | 136_ISB | 137_HYD | 137_AFF | 137_AEF | 137_HBD | 137_HBA | 137_PSB | 137_NSB | 137_ISB | 138_HYD | 138_AFF | 138_AEF | 138_HBD | 138_HBA | 138_PSB | 138_NSB | 138_ISB | 139_HYD | 139_AFF | 139_AEF | 139_HBD | 139_HBA | 139_PSB | 139_NSB | 139_ISB | 140_HYD | 140_AFF | 140_AEF | 140_HBD | 140_HBA | 140_PSB | 140_NSB | 140_ISB | 141_HYD | 141_AFF | 141_AEF | 141_HBD | 141_HBA | 141_PSB | 141_NSB | 141_ISB | 142_HYD | 142_AFF | 142_AEF | 142_HBD | 142_HBA | 142_PSB | 142_NSB | 142_ISB | 145_HYD | 145_AFF | 145_AEF | 145_HBD | 145_HBA | 145_PSB | 145_NSB | 145_ISB | 146_HYD | 146_AFF | 146_AEF | 146_HBD | 146_HBA | 146_PSB | 146_NSB | 146_ISB | 147_HYD | 147_AFF | 147_AEF | 147_HBD | 147_HBA | 147_PSB | 147_NSB | 147_ISB | 164_HYD | 164_AFF | 164_AEF | 164_HBD | 164_HBA | 164_PSB | 164_NSB | 164_ISB | 165_HYD | 165_AFF | 165_AEF | 165_HBD | 165_HBA | 165_PSB | 165_NSB | 165_ISB | 166_HYD | 166_AFF | 166_AEF | 166_HBD | 166_HBA | 166_PSB | 166_NSB | 166_ISB | 167_HYD | 167_AFF | 167_AEF | 167_HBD | 167_HBA | 167_PSB | 167_NSB | 167_ISB | 168_HYD | 168_AFF | 168_AEF | 168_HBD | 168_HBA | 168_PSB | 168_NSB | 168_ISB | 169_HYD | 169_AFF | 169_AEF | 169_HBD | 169_HBA | 169_PSB | 169_NSB | 169_ISB | 170_HYD | 170_AFF | 170_AEF | 170_HBD | 170_HBA | 170_PSB | 170_NSB | 170_ISB | 171_HYD | 171_AFF | 171_AEF | 171_HBD | 171_HBA | 171_PSB | 171_NSB | 171_ISB | 172_HYD | 172_AFF | 172_AEF | 172_HBD | 172_HBA | 172_PSB | 172_NSB | 172_ISB | 400_HYD | 400_AFF | 400_AEF | 400_HBD | 400_HBA | 400_PSB | 400_NSB | 400_ISB | 401_HYD | 401_AFF | 401_AEF | 401_HBD | 401_HBA | 401_PSB | 401_NSB | 401_ISB | 402_HYD | 402_AFF | 402_AEF | 402_HBD | 402_HBA | 402_PSB | 402_NSB | 402_ISB | 403_HYD | 403_AFF | 403_AEF | 403_HBD | 403_HBA | 403_PSB | 403_NSB | 403_ISB | 404_HYD | 404_AFF | 404_AEF | 404_HBD | 404_HBA | 404_PSB | 404_NSB | 404_ISB | 405_HYD | 405_AFF | 405_AEF | 405_HBD | 405_HBA | 405_PSB | 405_NSB | 405_ISB | 406_HYD | 406_AFF | 406_AEF | 406_HBD | 406_HBA | 406_PSB | 406_NSB | 406_ISB | 407_HYD | 407_AFF | 407_AEF | 407_HBD | 407_HBA | 407_PSB | 407_NSB | 407_ISB | 409_HYD | 409_AFF | 409_AEF | 409_HBD | 409_HBA | 409_PSB | 409_NSB | 409_ISB | 410_HYD | 410_AFF | 410_AEF | 410_HBD | 410_HBA | 410_PSB | 410_NSB | 410_ISB | 411_HYD | 411_AFF | 411_AEF | 411_HBD | 411_HBA | 411_PSB | 411_NSB | 411_ISB | 412_HYD | 412_AFF | 412_AEF | 412_HBD | 412_HBA | 412_PSB | 412_NSB | 412_ISB | 413_HYD | 413_AFF | 413_AEF | 413_HBD | 413_HBA | 413_PSB | 413_NSB | 413_ISB | 414_HYD | 414_AFF | 414_AEF | 414_HBD | 414_HBA | 414_PSB | 414_NSB | 414_ISB | 415_HYD | 415_AFF | 415_AEF | 415_HBD | 415_HBA | 415_PSB | 415_NSB | 415_ISB | 416_HYD | 416_AFF | 416_AEF | 416_HBD | 416_HBA | 416_PSB | 416_NSB | 416_ISB | 417_HYD | 417_AFF | 417_AEF | 417_HBD | 417_HBA | 417_PSB | 417_NSB | 417_ISB | 418_HYD | 418_AFF | 418_AEF | 418_HBD | 418_HBA | 418_PSB | 418_NSB | 418_ISB | 562_HYD | 562_AFF | 562_AEF | 562_HBD | 562_HBA | 562_PSB | 562_NSB | 562_ISB | 563_HYD | 563_AFF | 563_AEF | 563_HBD | 563_HBA | 563_PSB | 563_NSB | 563_ISB | 564_HYD | 564_AFF | 564_AEF | 564_HBD | 564_HBA | 564_PSB | 564_NSB | 564_ISB | 565_HYD | 565_AFF | 565_AEF | 565_HBD | 565_HBA | 565_PSB | 565_NSB | 565_ISB | 566_HYD | 566_AFF | 566_AEF | 566_HBD | 566_HBA | 566_PSB | 566_NSB | 566_ISB | 578_HYD | 578_AFF | 578_AEF | 578_HBD | 578_HBA | 578_PSB | 578_NSB | 578_ISB | 579_HYD | 579_AFF | 579_AEF | 579_HBD | 579_HBA | 579_PSB | 579_NSB | 579_ISB | 580_HYD | 580_AFF | 580_AEF | 580_HBD | 580_HBA | 580_PSB | 580_NSB | 580_ISB | 581_HYD | 581_AFF | 581_AEF | 581_HBD | 581_HBA | 581_PSB | 581_NSB | 581_ISB | 582_HYD | 582_AFF | 582_AEF | 582_HBD | 582_HBA | 582_PSB | 582_NSB | 582_ISB | 583_HYD | 583_AFF | 583_AEF | 583_HBD | 583_HBA | 583_PSB | 583_NSB | 583_ISB | 584_HYD | 584_AFF | 584_AEF | 584_HBD | 584_HBA | 584_PSB | 584_NSB | 584_ISB | 585_HYD | 585_AFF | 585_AEF | 585_HBD | 585_HBA | 585_PSB | 585_NSB | 585_ISB | 586_HYD | 586_AFF | 586_AEF | 586_HBD | 586_HBA | 586_PSB | 586_NSB | 586_ISB | 587_HYD | 587_AFF | 587_AEF | 587_HBD | 587_HBA | 587_PSB | 587_NSB | 587_ISB | 588_HYD | 588_AFF | 588_AEF | 588_HBD | 588_HBA | 588_PSB | 588_NSB | 588_ISB | 589_HYD | 589_AFF | 589_AEF | 589_HBD | 589_HBA | 589_PSB | 589_NSB | 589_ISB | 590_HYD | 590_AFF | 590_AEF | 590_HBD | 590_HBA | 590_PSB | 590_NSB | 590_ISB | 591_HYD | 591_AFF | 591_AEF | 591_HBD | 591_HBA | 591_PSB | 591_NSB | 591_ISB | 622_HYD | 622_AFF | 622_AEF | 622_HBD | 622_HBA | 622_PSB | 622_NSB | 622_ISB | 623_HYD | 623_AFF | 623_AEF | 623_HBD | 623_HBA | 623_PSB | 623_NSB | 623_ISB | 624_HYD | 624_AFF | 624_AEF | 624_HBD | 624_HBA | 624_PSB | 624_NSB | 624_ISB | 625_HYD | 625_AFF | 625_AEF | 625_HBD | 625_HBA | 625_PSB | 625_NSB | 625_ISB | 626_HYD | 626_AFF | 626_AEF | 626_HBD | 626_HBA | 626_PSB | 626_NSB | 626_ISB | 627_HYD | 627_AFF | 627_AEF | 627_HBD | 627_HBA | 627_PSB | 627_NSB | 627_ISB | 628_HYD | 628_AFF | 628_AEF | 628_HBD | 628_HBA | 628_PSB | 628_NSB | 628_ISB | |
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| 6ZGC_D_H8H_1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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